Leveraging genetic and phenotypic variation to discover metabolite-protein interactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41192359.
- Also identified by DOI 10.1016/j.cmet.2025.10.008.
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Abstract
How metabolites regulate protein function is still poorly understood. Leveraging the power of genetic variation, Xiao et al. built a global protein-metabolite covariation dataset to reveal novel protein-metabolite regulations in mouse that led to the discovery of cysteine catabolism as an unexpected regulator of cholesterol.
Medical subject headings
- Genetic Variation
- Proteins