Psychometric properties of MFM32 in Myotonic Dystrophy type 1.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 41192792.
- Also identified by DOI 10.1016/j.apmr.2025.10.013.
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Abstract
To examine the psychometric properties of the Motor Function Measure 32 (MFM32) in adults with Myotonic Dystrophy type 1(DM1). MFM32 is an instrument for evaluating function in neuromuscular diseases that have not been adequately assessed in DM1. Cross-sectional study using video recording of the performance for evaluation of intra- and inter- rater reliability. Data collection was performed at five different sites (three neurological departments, one rehabilitation center and one center for rare disorders) and in several of the participants' home. Convenience sample of 86 adults with DM1. Not applicable. MFM32. The objective was to assess internal consistency, intra- and inter-rater reliability, measurement error, convergent validity, and floor and ceiling effects of MFM32 in adults with DM1. We analyzed the total percentage score and the three domain scores: D1 (standing and transfers), D2 (axial and proximal motor function) and D3 (distal motor function). Internal consistency measured by Cronbach's alpha for the total percentage score was 0.94. For the three domains it was 0.95 (D1), 0.70 (D2) and 0.66 (D3). The intra-rater reliability coefficients were excellent (ICC<sub>2.1</sub>= 0.96-0.99), and the inter-rater reliability coefficients were good-to-excellent (ICC<sub>2.1</sub>= 0.86-0.99). Standard error of measurement (SEM) of the total percentage score was 1.59 for the intra-rater reliability and 1.66 for the inter-rater reliability. Minimal detectable change (MDC) was 4.42 for the intra-rater reliability and 4.6 for the inter-rater reliability. Convergent validity was medium to high. There was a tendency for a ceiling effect on the total percentage score, as well as on some of the domain percentage scores. MFM32 has a high internal consistency, intra- and inter- rater reliability, and convergent validity in adults with DM1. Calculated SEM and MDC were low. There is a ceiling effect of MFM32, especially in the distal function domain (D3) and among the participants with high motor function.