LDBT instead of DBTL: combining machine learning and rapid cell-free testing.

Clark-ElSayed, Alia; Harrison, Isa Madrigal; Olsen, Meagan L; Lazar, John T; Jewett, Michael C; Ellington, Andrew D · Nat Commun · 2025

basic_science · Level V

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Abstract

Synthetic biology is defined by Design-Build-Test-Learn cycles. Recent advances in machine learning are changing the landscape; thus, we propose that “Learning” can precede “Design”. Moreover, adopting cell-free platforms can further accelerate “Building” and “Testing” for megascale data generation and models.