OpTiles: an R package for adaptive tiling and methylation variability profiling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41206940.
- Also identified by DOI 10.1093/bioinformatics/btaf614 and PMC identifier 12646143.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data. OpTiles is implemented in R and source code is freely available at https://github.com/fhaive/OpTiles. Data are available on Zenodo at https://doi.org/10.5281/zenodo.16961292.
Medical subject headings
- DNA Methylation
- Software
- Sequence Analysis, DNA