Model validation confirms variable relative biological effectiveness and elevated periventricular sensitivity after proton therapy of brain tumors.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 41207632.
- Also identified by DOI 10.1016/j.radonc.2025.111271.
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Abstract
This study validates recently proposed voxel-wise and patient-wise predictive models for localization and occurrence of late radiation-induced contrast enhancements after proton therapy for brain tumors. Using an independent patient cohort, we confirmed the models' accuracy and reliability, emphasizing an increased radiosensitivity in periventricular regions and a linear-energy-transfer-dependent relative biological effectiveness.
Medical subject headings
- Brain Neoplasms
- Proton Therapy