s-Block Atomic Calcium Sites Boost Biomimetic Hydrolysis for Personal Protection.

Abstract

Organophosphorus compounds (OPs) are highly toxic to neural centers by causing irreversible damage, while the native neurometabolic system of mammals relying on paraoxonase 1 shows less detoxification efficiency. Personal protective equipment integrating nanozyme is promising to construct an artificial OP metabolism system for efficient detoxification, yet a robust nanozyme featuring nearly instantaneous detoxification is still vacant. Herein, a ceria nanozyme anchoring s-block atomic calcium sites (Ca-CeO₂) is designed by mimicking paraoxonase 1 for OP hydrolytic detoxification with an ultrashort half-life of 1.64 min. The s-block Ca site with a strong Lewis acid is characterized by the broad p orbital, which is easier to couple with the orbital of O atoms in the phosphoryl group and nucleophilic hydroxyl group than the Ce site, enhancing the adsorption and attack on the substrate. Benefiting from the satisfying detoxification efficiency, a Ca-CeO₂ metabolism system is successfully integrated into a protective mask for personal protection.