Microvascular Dysfunction Assessed by 82 Rb PET/CT as a Diagnostic Tool of Chronic Active Myocarditis.

Bailly, Matthieu; Sannier, Aurélie; Ou, Phalla; Malmare, Angela; Arangalage, Dimitri · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Immune-related myocarditis may be challenging. We report the case of a 66-year-old man with a history of treated multiple myeloma by using immune checkpoint blockers, referred for angina. Coronary angiography was normal. [ 82 Rb]Rubidium PET/CT found diffuse abnormal stress myocardial blood flow and reserve and the apparition of epicardial calcifications. [ 68 Ga]Ga-DOTATOC PET/CT and CMR revealed chronic calcified myocarditis, which was confirmed by histology. This case emphasizes microvascular dysfunction in chronic active myocarditis as assessed by perfusion PET/CT.

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