Study on the mechanism of hUCMSCs-derived 3D exosome combined with HAMA microneedles in the treatment of deep second-degree burns.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41234297.
- Also identified by DOI 10.1016/j.bioactmat.2025.09.031 and PMC identifier 12607139.
- Licence recorded as CC BY-NC-ND.
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Abstract
Burn wound healing remains challenging due to uncontrolled inflammation and poor angiogenesis. We developed hyaluronic acid methacryloyl microneedles (EXO@HAMA) loaded with 3D-cultured mesenchymal stem cell (MSC) exosomes to overcome limitations of growth factor therapies and sudden release of exosomes. 3D-exosomes potently enhanced fibroblast proliferation and endothelial tube formation. In rat deep second-degree burns, EXO@HAMA reduced inflammation and accelerated healing through CTSB/TGF-β and Wnt/β-catenin axis modulation, significantly improving collagen deposition and angiogenesis. Transcriptomics revealed activation of lipid metabolism and extracellular matrix (ECM) remodeling. This work demonstrates 3D-exosome/HAMA synergy in resolving inflammation-angiogenesis imbalance, offering a clinically promising strategy for burn regeneration.