Swift-acting structured lattice-enhanced caramelized sucrose system for painless sedative delivery.

Abstract

Dexmedetomidine, known as an exceptionally potent and highly selective α2-adrenergic receptor agonist, is widely used as a safe and effective intravenous sedative agent in both surgical and nonsurgical settings. As the need for an optimized sedative delivery system grows-one that is not only easy to apply but also demonstrates superior efficacy, particularly among pediatric patients and other groups with lower levels of cooperation-innovative delivery methods are increasingly sought. To address this need, we developed a caramelized amorphous sucrose-based lunging microneedle array (CALM), incorporating an advanced Kelvin cell lattice framework. This lattice improves the microneedle array's surface contact with tissues, accelerating and enhancing the drug release process. Additionally, unlike conventional sucrose-based microneedles, which often crystallize and lose mechanical strength, the caramelization process reduces crystallinity, increasing both the stability and structural integrity of the system. These combined features make CALM a highly effective and patient-friendly option for administering dexmedetomidine. Preliminary trials in clinical simulations showed a rapid onset of sedation with minimal discomfort, highlighting its potential as a promising solution for vulnerable populations needing fast and secure sedation.