MicroRNA-mediated metabolic disruption as an emerging driver of alcohol use disorder.
Where this comes from
- Record sourced from PubMed, PMID 41249205.
- Also identified by DOI 10.1038/s41467-025-65743-7 and PMC identifier 12623994.
- Licence recorded as CC BY-NC-ND.
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Abstract
Previous research has sought to determine the underlying mechanisms that govern the development of Alcohol Use Disorder (AUD). In a recent study by Ehinger et al., excessive alcohol consumption utilizes mTORC1’s under characterized role in repressing mRNA translation through the upregulation of microRNAs, specifically in a D1-circuit-specific manner, resulting in repression of glycolysis in the brain’s reward pathway.