First Report of Treatment-Emergent Resistance to Cefepime-Zidebactam in Pseudomonas aeruginosa.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 41251222.
- Also identified by DOI 10.1093/cid/ciaf638.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We describe the first case of cefepime-zidebactam treatment-emergent resistance associated with clinical failure in a patient with Pseudomonas aeruginosa pneumonia. During treatment, cefepime-zidebactam minimum inhibitory concentrations increased from 8/8 to 32/32 mg/L. Whole-genome sequence analysis showed new mutations in the MexAB-OprM efflux operon that were associated with cross-resistance to ceftazidime-avibactam and imipenem-relebactam.
Medical subject headings
- Cefepime
- Pseudomonas aeruginosa
- Azabicyclo Compounds
- Cephalosporins
- Anti-Bacterial Agents
- Pseudomonas Infections
- Cyclooctanes
- Drug Resistance, Multiple, Bacterial
- Drug Resistance, Bacterial