Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41252208.
- Also identified by DOI 10.1172/jci.insight.194624 and PMC identifier 12890470.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Natural opioid signals in the brain produced by Met-enkephalin-Arg-Phe are enhanced after blocking its degradation by the N-terminal catalytic domain of angiotensin-converting enzyme.
Medical subject headings
- Brain
- Angiotensin-Converting Enzyme Inhibitors
- Peptidyl-Dipeptidase A
- Opioid Peptides