Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41252215.
- Also identified by DOI 10.1172/JCI192454 and PMC identifier 12807462.
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Abstract
Using an advanced human lung-on-a-chip model, this study shows that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.
Medical subject headings
- Pseudomonas aeruginosa
- Pseudomonas Infections
- Organoids
- Lab-On-A-Chip Devices
- Stress, Mechanical
- Lung
- Models, Biological
- Pneumonia
- Pneumonia, Bacterial