Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice.

Olcott, Flora; Oddie, Philip D; Barlow, Maeve J; Mamarelis, Athanasios; Byott, Matthew; Grant, Paul; Botha, Johannes; Booth, Clare et al. · Clin Infect Dis · 2025

case_series · Level IV

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Abstract

The potential for hepatitis B reactivation must be considered when switching people with HIV and prior hepatitis B exposure away from tenofovir-containing combined anti-retroviral therapy. Four cases of hepatitis B reactivation from the United Kingdom are presented. Hepatitis B mutations, risk factors and pre- and post-switch recommendations are explored.