Bench-stable reagents for modular access to persulfuranyl scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41261106.
- Also identified by DOI 10.1038/s41467-025-63621-w and PMC identifier 12630828.
- Licence recorded as CC BY-NC-ND.
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Abstract
Pentafluorosulfanyl group has been long considered a potential (bio)isostere for tert-butyl and trifluoromethyl groups, yet limitations in methodologies have constrained access to it. To bridge this gap, we have developed a general pentafluorosulfanylation platform that employs bench-stable solid reagents to generate SF<sub>5</sub> radicals via a decarboxylation and β-scission sequence. This strategy enables a variety of operationally simple transformations, expanding the accessibility of SF<sub>5</sub>-containing molecules. Notably, this reagent design is also adaptable to other persulfuranyl groups, such as trifluoromethyl tetrafluorosulfanyl and aryl tetrafluorosulfanyl groups. Taken together, generating a collection of these stable reagents and practitioner-friendly chemical methodologies enables the synthesis of challenging and biologically relevant sulfur(VI) chemical entities in an expedient manner.