Untangling causality in nephrology: the example of CKD-MBD and disease progression.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41271314.
- Also identified by DOI 10.1016/j.kint.2025.08.017.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This commentary highlights the innovative use of the g-formula in the European QUALity (EQUAL) study to untangle the causal relationship between chronic kidney disease-mineral and bone disorder biomarkers and kidney disease progression. By addressing time-varying confounding, informative censoring, and competing risks, this approach moves beyond traditional association studies. However, as an observational study, it remains limited by the data collected. The next step is to demonstrate that lowering serum phosphate can effectively slow chronic kidney disease progression.
Medical subject headings
- Renal Insufficiency, Chronic
- Chronic Kidney Disease-Mineral and Bone Disorder