Predictive modeling & mechanistic validation of synergistic pimodivir combinations for anti-influenza therapy via PB2cap affinity boost.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41272280.
- Also identified by DOI 10.1038/s41746-025-02083-2 and PMC identifier 12638785.
- Licence recorded as CC BY-NC-ND.
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Abstract
This study introduces a machine learning framework to predict effective antiviral combinations for influenza A. It identifies Pimodivir with Epinephrine or L-Adrenaline as synergistic agents, confirmed by experiments demonstrating increased binding affinity and viral suppression. Multiple synergy scoring methods validate these drug combinations' potential, offering a strategic pathway for designing rational combination therapies against influenza and other RNA viruses.