Biventricular adaptation after patent ductus arteriosus ligation.
Where this comes from
- Record sourced from PubMed, PMID 41272299.
- Also identified by DOI 10.1038/s41390-025-04615-8 and PMC identifier 13221303.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Patent ductus arteriosus closure is followed by major adaptive changes in cardiac loading conditions, which may be associated with hemodynamic instability in some patients secondary to left ventricular systolic and diastolic dysfunction. Conventional echocardiography measures, including ejection fraction, have poor sensitivity for early detection of impaired left ventricular dysfunction. Speckle Tracking Echocardiography, which allows characterization of atrial and ventricular strain, may be an earlier and more sensitive marker of abnormal heart function. Recent guidelines suggest incorporation of speckle tracking echocardiography into multiparametric assessments of heart function in neonates. Its use may enhance clinical decision-making by improving early detection of dysfunction and enabling more accurate risk stratification following PDA closure.