Prediction of preeclampsia at 11-14 weeks of pregnancy by using FMF score with a history and uterine artery doppler: A prospective study.

Abstract

Preeclampsia is a pregnancy-specific hypertensive disorder with serious complications contributing to high maternal and fetal morbidity. It is to predict preeclampsia at 11-14 weeks of pregnancy with the objective of comparing sensitivity, specificity, PPV, NPV of FMF Score with a history and on adding color doppler. This was a prospective cohort study of 1 year duration in antenatal women between 11 and 14 weeks of gestation visiting IGIMS antenatal OPD for screening of preeclampsia after taking the consent. The research comprised individuals who were prepared to be followed up after a single-ton pregnancy. There was a significant difference (W = 1876.500, <i>P</i> = 0.006), with the median MAP (mmHg) being highest in the preeclampsia group. There was a moderate negative correlation between Mean PI and Final FMF Score with History + Doppler, and this correlation was statistically significant (rho = -0.35, <i>P</i> = 0.002). In the present study, the final FMF score using history alone (cutoff: <150) demonstrated a sensitivity of 82.4%, specificity of 53.4%, PPV of 40.6%, NPV of 88.7%, and diagnostic accuracy of 61.5%. When Doppler findings were included (history + Doppler), the final FMF score (cutoff: <150) showed a sensitivity of 67.6%, specificity of 90.9%, PPV of 74.2%, NPV of 87.9%, and diagnostic accuracy of 84.4%. This screening test enables us to predict preeclampsia before its clinical presentation. It can be used as a reliable and a cost-effective screening test.