TRENDS IN THE ULCERATIVE COLITIS TO CROHN'S DISEASE INCIDENCE RATIO ARE DISTINCT BETWEEN EPIDEMIOLOGIC STAGES OF INFLAMMATORY BOWEL DISEASE.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 41284467.
- Also identified by DOI 10.14309/ajg.0000000000003868.
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Abstract
The ulcerative colitis (UC) to Crohn's disease (CD) incidence ratio varies across geography and time. We analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis. Ratios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: -0.12; 95%CI: -0.66, 0.42). Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.