Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41284739.
- Also identified by DOI 10.1093/infdis/jiaf598 and PMC identifier 13017197.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Three critically ill or fatal avian influenza A(H5N1) human infections have been reported in North America since November 2024. Notably, all were infected with genotype D1.1 instead of B3.13, the dominant genotype before November 2024. Here, we demonstrated that D1.1 could replicate to higher titers in human nasal and airway organoid-derived transwell monolayers from 6 donors. D1.1 exhibited a better binding to α2,3- and α2,6-linked sialic acid than B3.13. No significant differences in most inflammatory or antiviral cytokines/chemokines were observed. These observations suggest that D1.1 is better adapted to both the upper and lower human respiratory tract epithelium than B3.13.
Medical subject headings
- Influenza A Virus, H5N1 Subtype
- Influenza, Human
- Organoids
- Respiratory Mucosa
- Respiratory System