Solvent-mediated chirality inversion in orthogonal hierarchical assembly of achiral carbene-anchored gold cluster.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41298441.
- Also identified by DOI 10.1038/s41467-025-65637-8 and PMC identifier 12657935.
- Licence recorded as CC BY-NC-ND.
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Abstract
Precisely constructing homochiral helical nanostructures from achiral molecules by non-covalent interactions remains challenging owing to the untraceable handedness control at different hierarchical levels. Here, we present an aurophilicity-assisted orthogonal assembly strategy, enabling not only the homochiral assembly of an achiral carbene-anchored trinuclear gold cluster with chiral amines but also the inversion of circularly polarized luminescence (CPL). This gold cluster could spontaneously form random right- or left-handed helices, while introduction of chiral amines effectively drives the formation of hierarchically homochiral twists with |g<sub>lum</sub>| of 10<sup>-2</sup>, directed by inherent aurophilicity of gold cluster and orthogonal intermolecular C-H⋅⋅⋅O/N interactions. Furthermore, by fine-tuning the assembly conditions from DMF to DMF/H<sub>2</sub>O solvent, the morphology of assemblies can be specifically controlled, resulting in inversion of CPL signals. This study highlights the potential of aurophilicity-driven orthogonal assembly strategy in effectively controlling hierarchical chirality and paves the way for advancing chiral metallo-superstructures.