Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41298588.
- Also identified by DOI 10.1038/s41536-025-00443-w and PMC identifier 12657993.
- Licence recorded as CC BY-NC-ND.
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Abstract
Peripheral nerve injuries beyond 5 cm lack effective treatments. Functional nerve guidance conduits (NGCs) have emerged as transformative tools orchestrating regeneration by leveraging Schwann cell (SC)-centric mechanisms. This review comprehensively analyzes how NGC designs modulate SC behavior through three synergistic axes: physical cues, biochemical signaling, and bioelectric regulation. By enhancing microenvironmental regulation, next-generation NGCs aim to surpass autograft efficacy, offering scalable solutions for functional nerve recovery and improved patient outcomes.