Activation-induced cytidine deaminase: The missing piece of many puzzles.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41308615.
- Also identified by DOI 10.1016/j.cell.2025.10.031.
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Abstract
Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of antibody specificity, and a baffling human immunodeficiency were traced to the action of one enzyme: activation-induced cytidine deaminase (AID).
Medical subject headings
- Cytidine Deaminase