Artificial intelligence to shed light on the algal dark proteomes.
basic_science · Level V
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- Record sourced from PubMed, PMID 41328161.
- Also identified by DOI 10.1016/j.patter.2025.101421 and PMC identifier 12664948.
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Abstract
Nelson et al. developed LA⁴SR, a large-scale language-model framework to classify translated open reading frames (ORFeomes) across ten algal phyla. LA⁴SR achieves near-complete protein classification coverage even for algal dark proteomes, where alignment tools often return "no hit." The framework provides a leap forward for high-throughput protein classification in algae and could be a promising tool for better classifying proteins from many organisms.