An MRI radiomics approach using invasion-based weak supervision for identifying and evaluating aggressive PitNETs.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 41331080.
- Also identified by DOI 10.1038/s41746-025-02189-7 and PMC identifier 12780281.
- Licence recorded as CC BY-NC-ND.
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Abstract
Pituitary neuroendocrine tumor (PitNET) aggressiveness critically affects treatment and prognosis, yet reliable noninvasive preoperative tools remain lacking. We developed a deep learning radiomics (DLR) model integrating automatic segmentation, feature extraction, selection, and DLR score computation, trained on the training cohort and validated on the remaining cohorts (total n = 1089 from three medical centers). Using nnUnet and a fine-tuned Swin Transformer, 13 key features were identified to construct the model. The DLR score demonstrated strong correlation with Knosp and Hardy-Wilson invasion classifications, while outperforming them in predicting recurrence and indicating aggressive pathological markers (Ki-67, p53, macrophages) and revealing biological pathways (MAPK, TGF-β). The model was further implemented into an online platform, enabling clinical deployment. This noninvasive preoperative approach provides a robust imaging biomarker for identifying and evaluating PitNET aggressiveness and may support individualized treatment strategies.