Adipose whispers to mast cells for accelerating immune evasion in pancreatic cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41338175.
- Also identified by DOI 10.1016/j.cmet.2025.10.018.
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Abstract
The mechanisms connecting obesity to pancreatic cancer progression remain poorly defined. A new study reveals that extracellular vesicles from visceral adipose tissue reprogram immune cells through a cathepsin A-pseudouridine-mast cell axis, uncovering how obesity drives immune evasion and resistance to checkpoint blockade therapy in pancreatic cancer.
Medical subject headings
- Pancreatic Neoplasms
- Mast Cells
- Immune Evasion
- Adipose Tissue