Tumor acidosis: Fusing mitochondrial dynamics and lipid metabolism.
Where this comes from
- Record sourced from PubMed, PMID 41338176.
- Also identified by DOI 10.1016/j.cmet.2025.11.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cancer cells experience multiple stresses within tumors, stemming from elevated metabolic activity, including nutrient shortage, waste buildup, hypoxia, and acidosis. According to Groessl et al.,<sup>1</sup> acidosis is the dominant environmental factor offering metabolic flexibility to support tumor fitness and resilience to the other stresses by promoting mitochondria fusion and enhancing respiration capacity.
Medical subject headings
- Acidosis
- Lipid Metabolism
- Mitochondria
- Mitochondrial Dynamics
- Neoplasms