Microbial metabolites shape mammalian protein translation.
basic_science · Level V
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- Record sourced from PubMed, PMID 41338177.
- Also identified by DOI 10.1016/j.cmet.2025.11.003.
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Abstract
Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ<sub>1</sub>), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation.
Medical subject headings
- Protein Biosynthesis
- Nucleoside Q
- Bacteria