Integrative application of traditional Chinese medicine and internal fixation in complex distal radius fractures: Clinical value of Xiaozhong Zhitong ointment combined with volar locking plate in AO-C2/3 injuries.

Xu, Jiachen; Zhu, Weiyan; Gu, Jun; Feng, Zheng · J Orthop Surg (Hong Kong) · 2025

rct · Level II

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Abstract

ObjectiveThis study assesses the clinical efficacy and safety of combining traditional Chinese medicine (TCM) external therapy (Xiaozhong Zhitong ointment) with volar locking plate (VLP) fixation for treating complex AO-C2/3 distal radius fractures.MethodsSixty patients with complex AO-C2/3 distal radius fractures were randomly assigned into two groups (n = 30 each). The control group received standard VLP fixation alone, while the study group additionally received external application of Xiaozhong Zhitong ointment postoperatively. Clinical endpoints included Visual Analogue Scale (VAS) score, swelling condition, Cooney scores, Generic Quality of Life Inventory-74 (GQOL-74) score, radiographic parameters (palmar tilt, ulnar variance, radial height, joint surface displacement), wrist joint mobility (flexion, extension, pronation, supination, radial and ulnar inclination), and incidence of complications.ResultsCompared to the control group, at 2- and 4-weeks postoperatively, the study group showed lower VAS scores and swelling levels (<i>p</i> < 0.05). The study group also exhibited higher Cooney scores at 4 weeks and 6 months postoperatively and excellent-good rate of Cooney scores at 6 months postoperatively. Additionally, the study group demonstrated better GQOL-74 scores across all dimensions at 6 months postoperatively, along with improved imaging parameters (palmar tilt, ulnar deviation, joint surface displacement) and greater wrist flexion range of motion at 12 months postoperatively (all <i>p</i> < 0.05). There was no significant difference in complication rates between the two groups (<i>p</i> > 0.05).ConclusionCombining Xiaozhong Zhitong ointment with VLP fixation improves outcomes for complex distal radius fractures, reducing pain and swelling, enhancing quality of life and wrist function, with no added complication risk, making it a potential adjunct to standard care.

Medical subject headings

Anatomy