Unlocking human brain networks by assembling circuits in vitro and in vivo.
basic_science · Level V
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- Record sourced from PubMed, PMID 41349522.
- Also identified by DOI 10.1016/j.stem.2025.10.011.
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Abstract
In this issue of Cell Stem Cell, Wang et al.<sup>1</sup> generate human nucleus basalis of Meynert organoids (hnbMOs), establish a human-specific cholinergic projection system in transplanted assembloids, and identify projection deficits in Down syndrome-derived assembloids. This study provides a valuable model for investigating nbM-related neural circuits and neurological disorders.
Medical subject headings
- Brain
- Nerve Net