The PRINCE trial of remote ischaemic preconditioning in noncardiac surgery to reduce myocardial injury: sign o' the times.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 41350217.
- Also identified by DOI 10.1016/j.bja.2025.11.005.
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Abstract
The remote ischemic PReconditioning In Non-Cardiac surgEry (PRINCE) trial was a multinational, double-blind trial in which 1213 patients undergoing noncardiac surgical procedures were randomly assigned to receive remote ischaemic preconditioning (RIPC) or sham-RIPC after general anaesthesia and before surgery to reduce myocardial injury. Postoperative myocardial injury, defined alone by postoperative high-sensitivity troponin above the highest 99th percentile of reference values, occurred in 215/566 patients (38.0%) in the RIPC group and in 223/596 patients (37.4%) in the sham-RIPC group. The PRINCE trial adds to an apparently contradictory literature on the role of RIPC in perioperative medicine. We discuss both trial-specific and mechanistic reasons to explain these discrepancies, and we contend that a role for RIPC in minimising organ injury as a result of noncardiac surgery remains possible.
Medical subject headings
- Ischemic Preconditioning
- Ischemic Preconditioning, Myocardial
- Myocardial Reperfusion Injury
- Postoperative Complications
- Surgical Procedures, Operative