PSMA PET/CT Reveals Pituitary Renal Cell Carcinoma Metastasis Mimicking Immune-Related Hypophysitis.
case_report · Level V
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- Record sourced from PubMed, PMID 41358843.
- Also identified by DOI 10.1097/RLU.0000000000006224.
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Abstract
Pituitary metastasis from renal cell carcinoma (RCC) is exceedingly rare and may mimic pituitary macroadenoma. We report a 62-year-old man with a history of RCC and immune checkpoint inhibitor-induced hypothyroidism who presented with persistent headaches and hypopituitarism. PSMA PET/CT revealed intense uptake in a sellar lesion, raising suspicion of metastasis. Histology following transsphenoidal surgery confirmed RCC metastasis. This case underscores the utility of PSMA PET/CT in RCC staging and restaging, especially helpful in detecting atypical metastases, and highlights the challenge of differentiating metastasis from macroadenoma and immunotherapy-related complications.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Pituitary Neoplasms
- Antigens, Surface
- Glutamate Carboxypeptidase II
- Hypophysitis