Visualization of the Gallbladder on 177 Lu-FAP-2286 SPECT/CT Imaging : A Potential Pitfall.
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- Record sourced from PubMed, PMID 41359364.
- Also identified by DOI 10.1097/RLU.0000000000006209.
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Abstract
Fibroblast activation protein (FAP) is a membrane-bound protease predominantly expressed on the surface of cancer-associated fibroblasts activated within the solid tumor microenvironment, while its expression remains minimal in normal tissues. Following radiolabeling, FAP-2286 has demonstrated favorable diagnostic performance and promising therapeutic potential in cancer. The image illustrates the accumulation of 177 Lu-FAP-2286 in the gallbladder, but correlative imaging and knowledge of the radiopharmaceutical helped to avoid a diagnostic pitfall.
Medical subject headings
- Gallbladder
- Gelatinases
- Lutetium
- Membrane Proteins
- Serine Endopeptidases
- Single Photon Emission Computed Tomography Computed Tomography