Lessons from niche-specific fitness of Staphylococcus aureus at the wound edge.

Ghatak, Subhadip; Muniz De Oliveira, Fabio · Nat Commun · 2025

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Abstract

<i>Staphylococcus aureus</i> persists in chronic diabetic wounds by adapting to their unique microenvironmental niche. Reconceptualizing pathogenesis as niche-specific ecological process highlights the need for therapies targeting wound-specific vulnerabilities and interspecies dynamics while leveraging immune components to disrupt pathogen–host adaptation.