Fractal-shaped droplet microfluidics for highly scalable cell mechanoporation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41370109.
- Also identified by DOI 10.1039/d5lc00865d.
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Abstract
Emerging non-viral gene delivery platforms provide alternatives to viral methods. However, they remain limited in scalability and efficiency for clinical translation. We present a fractal-shaped droplet microfluidic system that achieves approximately 98% efficiency and 80% viability at throughputs exceeding 10<sup>7</sup> cells per min, enabling efficient, large-scale, and clinically relevant cell engineering.
Medical subject headings
- Microfluidic Analytical Techniques
- Fractals
- Lab-On-A-Chip Devices