The promise of organ rejuvenation to overcome the shortage in organ transplantation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41372118.
- Also identified by DOI 10.1038/s41467-025-66133-9 and PMC identifier 12717245.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered. A substantial number of organs, particularly from older donors, remain unused due to concerns over age-related decline in quality. This review highlights emerging strategies to rejuvenate and optimize such organs by mitigating ischemia-reperfusion injury and reducing age-related immunogenicity. Advances in organ preservation, perfusion technologies, and novel therapies - including senotherapeutics, anti-inflammatory agents, and stem cell treatments - show promise in improving graft viability and bridging the gap between organ supply and demand.
Medical subject headings
- Rejuvenation
- Organ Transplantation
- Organ Preservation
- Tissue and Organ Procurement