A bioabsorbable body-coupling-electrotherapy suture.

Abstract

Sutures are pivotal medical devices for postoperative incision management. The inherent capacity of sutures to regulate wound healing and promote regeneration has the potential to significantly reduce patient discomfort and conserve medical resources. Here, we developed a bioabsorbable body-coupling electrotherapy suture that modulates healing from inflammation to remodeling, enabling healthy repair. The suture combines high tensile strength, flexibility, and degradability. The conversion of body-coupled electromagnetic energy through the suture enabled electrically synergistic therapeutic capabilities. By converting body-coupled electromagnetic energy, it provides synergistic therapy: dielectric polarization accelerates antimicrobial and anti-inflammatory effects, while dielectric voltage difference enhances healing factor expression. This fully physical approach reduces reliance on silver nanoparticles. In vitro and in vivo studies confirmed stable performance, achieving more than 1.43-fold improvement in healing efficiency compared with single-function sutures and reducing postoperative infections. Offering immobilization, stage-wide modulation, sustainability, and low energy demand, this technology represents a significant advancement in surgical practice.