Application of Acellular Dermal Matrix With or Without Flap Repair in Postoperative Defect Repair of Hypopharyngeal Carcinoma.

Abstract

The reconstruction of hypopharyngeal tumor defect after tumorectomy is essential. Artificial materials play an important role in the case of extensive defects and a relative lack of healthy tissue. This study aims to investigate the role of acellular dermal matrix (ADM) in repairing defects following hypopharyngeal carcinoma resection. A retrospective analysis was conducted on 280 patients with hypopharyngeal carcinoma. 143 patients accepted ADM-assisted reconstruction while 137 patients didn't. Data on postoperative deglutition function, respiratory function, and complications were collected and analyzed. No immune rejection response was observed. In partial laryngectomy, ADM significantly induces the time for hospitalization, decannulation, and oral food intake compared to the control group (p < 0.05). In total laryngectomy, ADM has advantages in terms of the number of individuals with good deglutition function (p < 0.05). There is no significant difference in pharyngocutaneous fistula. ADM is a promising biomaterial for reconstruction in hypopharyngeal carcinoma. It offers advantages such as a high success rate, good graft survival, accessibility, minimal immunogenicity, and simplified surgical procedures.