Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41386691.
- Also identified by DOI 10.1002/hed.70133 and PMC identifier 13055430.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it exerts antitumor effects similar to those in brain tumors and to explore its potential as a novel therapeutic target in HNSCC. We explored the significance of CLIC in HNSCC using cell biological analyses and investigated the gene expression profile of the CLIC2 forced-expressed HNSCC cell line. CLIC2 expression in human HNSCC was examined histopathologically. Forced expression of CLIC2 in HNSCC cells was accompanied by increased cell proliferation, resistance against natural killer cells, and expression of tumor-promoting genes in addition to increased tumorigenicity upon xenografting in a mouse model. CLIC2 expression was observed in several human cases of HNSCC. CLIC2 may act potentially as a novel risk factor for HNSCC.
Medical subject headings
- Chloride Channels
- Head and Neck Neoplasms
- Carcinoma, Squamous Cell