Health-Related Quality of Life in Patients Undergoing Surgery for Primary Hyperparathyroidism: Patient Reported Outcome Measures.

Abstract

Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective. Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worry survey; (2) Voice Handicap Index-10 (VHI-10); and (3) Patient-Reported Outcome Measurement Information System Global-10 (PROMIS). Forty-four patients were included with a median age of 65 years, with 39 females (89%) included. Thirty-two patients (73%) had a single adenoma, and 12 (27%) had multigland disease (parathyroid hyperplasia). Worry scores related to parathyroid cancer, parathyroid surgery, and parathyroid-related problems significantly improved post-operatively (p < 0.05). On PROMIS assessment, there were improved scores in the physical health domain, mental health domain, and general health following parathyroid surgery for PHPT (p < 0.05). Patients with PHPT demonstrated significant improvements in HRQL following surgery.