Rosai-Dorfman Disease Involving Thymus and Aorta Revealed by 18 F-FDG PET/CT.

Qi, Mengfang; Cheng, Junjun; Dai, Hongyuan; Huang, Rui · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis primarily involving lymph nodes, with occasional extranodal manifestations. Thymic and aortic involvement is exceptionally uncommon. We reported a case of a 33-year-old woman presenting with a mediastinal mass on 18 F-FDG PET/CT, revealing intense metabolic activity in the thymic region and thoracic aorta. Histopathology confirmed the diagnosis of RDD.

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