Prader-Willi syndrome: A rare genetic disorder with complex clinical manifestations.

Yadav, Dinkar; Yadav, Neha; Pruthi, Neha; Kumar, Sandeep; Bhalla, Kapil · J Family Med Prim Care · 2025

case_report · Level V

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Abstract

Prader-Willi Syndrome (PWS) is a rare genetic disorder characterised by hypotonia, hyperphagia, and developmental delay. We report a case of a 12-year-old girl who presented with excessive hunger, obesity, and cognitive impairment. Molecular analysis revealed a deletion of the paternal chromosomes 15q11-13, confirming the diagnosis of PWS. Our case highlights the importance of early diagnosis and multidisciplinary management in improving the quality of life for individuals with PWS.