Management of prediabetes and class III obesity in a 42-year-old male through One-Meal-a-Day.
case_report · Level V
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- Record sourced from PubMed, PMID 41403545.
- Also identified by DOI 10.4103/jfmpc.jfmpc_247_25 and PMC identifier 12704998.
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Abstract
A 42-year-old man with class III obesity (body mass index [BMI] ≈40 kg/m²), prediabetes (glycated hemoglobin (HbA1c) 6.2%), and stage-2 hypertension (≈150/95 mmHg) underwent a supervised lifestyle intervention. His diet was modified to a one-meal-a-day (OMAD) regimen emphasizing Dietary Approaches to Stop Hypertension (DASH)-style nutrition, coupled with regular exercise (swimming and walking). After three months, he lost ~10% of his body weight, with notable improvements in BMI, HbA1c, alanine aminotransferase (ALT), and blood pressure. Despite these gains, low-density lipoprotein (LDL) cholesterol paradoxically rose. We review recent literature on OMAD/intermittent fasting (IF), the effects of exercise on metabolism, and lifestyle management of obesity and prediabetes. The case outcomes largely align with evidence that IF plus exercise aids weight loss and glycemic control, but we discuss potential lipid risks and underscore the need for medical oversight. This case highlights a novel, patient-adapted regimen of OMAD/DASH and exercise, illustrating how intensive behavioral interventions can improve metabolic health while requiring careful monitoring of lipid changes.