Association Between Acute Kidney Injury, Delirium, and Outcomes in Patients With Critical Illness: A Systematic Review and Meta-Analysis.

Abstract

Acute kidney injury (AKI) and delirium are common complications of critical illness. However, relatively few studies have evaluated their relationship. We conducted a systematic synthesis and meta-analysis of existing evidence to clarify this association in critically ill patients. A comprehensive search was conducted across MEDLINE, Embase, CINAHL, Scopus, Web of Science, and Cochrane Library for publications reporting both AKI and delirium in ICUs patients from January 2000 to January 2025. AKI was defined according to serum creatinine or urine output criteria based on the contemporary definitions used in the individual studies. The primary outcome was the proportion of critically ill patients with AKI who developed delirium. Secondary outcomes included mortality and health service utilization. Pooled meta-analyses were summarized as effect sizes in proportions, risk ratios (RRs), odds ratios, or weighted mean differences (WMDs) using a random-effects model. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Eighteen observational studies comprising 158,694 patients were included. Overall study quality was moderate. The pooled proportion of delirium among patients with AKI was 32% (95% CI, 18-47%). Delirium was associated with higher mortality (RR, 2.36; 95% CI, 1.61-3.47; moderate certainty), greater renal replacement therapy use (RR, 3.12; 95% CI, 1.89-5.15; moderate certainty), longer ICU stays (WMD, 3.54 d; 95% CI, 1.20-5.87 d; moderate certainty), and longer hospital stays (WMD, 4.78 d; 95% CI, 3.48-6.09 d; moderate certainty) compared with patients with AKI not experiencing delirium. Delirium is common among critically ill patients with AKI and is associated with worse outcomes and greater health resource use.