An <i>in vitro</i> organ-on-chip model for studying neuron-keratinocyte interactions in sensory response through electrophysiology.
basic_science · Level V
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- Record sourced from PubMed, PMID 41405462.
- Also identified by DOI 10.1039/d5lc00867k.
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Abstract
This study introduces a human-relevant <i>in vitro</i> model using iPSC-derived sensory neurons and keratinocytes in MEA-integrated microfluidic chips. Neurons expressed nociceptor markers, showed TRPV activity, and formed contacts with keratinocytes. Stimuli evoked electrophysiological responses, highlighting neuron-keratinocyte interactions relevant to pruritus, pain, and skin disorders, supporting therapeutic development.
Medical subject headings
- Keratinocytes
- Lab-On-A-Chip Devices
- Sensory Receptor Cells
- Electrophysiological Phenomena
- Cell Communication
- Microfluidic Analytical Techniques