IgRENE: integrating gene regulatory networks and drug ontologies towards selected modification of target gene's expression.

Abstract

IgRENE is a web-based platform designed to integrate gene regulatory networks (GRNs) with drug-based regulatory data through a comprehensive, criteria-driven computational framework. The proposed tool provides a methodology for analyzing and identifying drugs along with their regulatory pathways, combining both upstream and downstream effects to assess the modulation of gene expression. This approach aids in prioritizing potential therapeutic compounds for more efficient further experimental validation and clinical testing. By consolidating gene-to-gene and drug-to-gene regulatory interactions within a unified interface, IgRENE provides researchers in drug discovery, systems biology, and precision medicine with a powerful tool that highlights drug candidates predicted to have a desired downstream effect on the expression of disease associated genes.