GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41406219.
- Also identified by DOI 10.1126/sciadv.aed8002 and PMC identifier 12710677.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
When two genes linked to increased Parkinson's risk converge on a lysosome, LRRK2 mutation enhances lysosomal release of soluble GPNMB potentially contributing to synuclein pathology.
Medical subject headings
- Lysosomes
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Parkinson Disease
- Exocytosis
- Membrane Glycoproteins