Emerging concepts and novel mechanisms in organ fibrosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41407703.
- Also identified by DOI 10.1038/s41536-025-00446-7 and PMC identifier 12711898.
- Licence recorded as CC BY-NC-ND.
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Abstract
Fibrosis, a maladaptive response characterized by excessive extracellular matrix deposition, disrupts tissue architecture and organ function. Recent advances reveal fibroblast heterogeneity across organs, with shared Postn<sup>+</sup> activated fibroblast subsets driving fibrogenesis. Emerging evidence links fibrosis to mechanical stress, metabolic rewiring, and non-coding RNA regulation, unveiling novel therapeutic targets. Innovative models and regenerative strategies - including senolytics, metabolic modulation, and in vivo reprogramming – hold promise to reverse fibrosis and promote tissue repair.