A bacterial nutrition strategy for plant disease control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41411414.
- Also identified by DOI 10.1126/science.ady8325 and PMC identifier 12807533.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
<i>Xanthomonas</i> spp. cause serious diseases in more than 400 plant species. The conserved AvrBs2 family effectors are among the most important virulence factors in xanthomonads, but how AvrBs2 promotes infection remains elusive. We found that AvrBs2 is a glycerophosphodiesterase-derived synthetase that catalyzes uridine 5'-diphosphate-α-d-galactose into a sugar phosphodiester, bis-(1,6)-cyclic dimeric α-d-galactose-phosphate, which is referred to as xanthosan. Xanthosan is synthesized by AvrBs2 in host cells and released into apoplastic spaces. <i>Xanthomonas</i> bacteria uptake xanthosan through the XanT transporter and hydrolyze it through the XanP phosphodiesterase for nutrition. AvrBs2, XanT, and XanP form a xanthosan "generation-uptake-utilization" system to provide a dedicated nutritional strategy to feed xanthomonads. Furthermore, elucidation of the AvrBs2-XanT-XanP virulence mechanism inspired us to develop an "anti-nutrition" strategy that should be applicable to control a wide variety of <i>Xanthomonas</i> diseases.
Medical subject headings
- Bacterial Proteins
- Phosphoric Diester Hydrolases
- Plant Diseases
- Virulence Factors
- Xanthomonas
- Crops, Agricultural